In addition to molecular stability, conformational analysis is used to predict reaction products.
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By exploiting this effect, conformational analysis can be used to design molecules that possess enhanced reactivity.
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The study of the energetics between different rotamers is referred to as "'conformational analysis " '.
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Using this new technique of conformational analysis, he later determined the geometry of many other natural product molecules.
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His research focused on new hydride reagents for asymmetric reduction, and the conformational analysis of phosphorus containing heterocycles.
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In addition, conformational analysis can be used to predict and explain product selectivity, mechanisms, and rates of reactions.
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One commonly cited example of the use of conformational analysis is a bi-molecular elimination reaction ( E2 ).
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Conformational analysis for the twist form is similar thus leading to the two forms being very close in energy.
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His research focussed on the stereochemistry and conformational analysis of flexible organic molecules, including derivatives of cyclohexane and saturated heterocyclic rings, using nuclear magnetic resonance spectroscopy ( NMR ) extensively.
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As a distinguished professor at Columbia University, Clark Still made significant contributions to the field of organic chemistry, particularly in the areas of natural product synthesis, reaction development, conformational analysis, macrocyclic stereocontrol, and computational chemistry.
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